The next approach I researched was the use of low intensity focused ultrasound (LIFU). Previously, scientists have struggled to get past the blood-brain barrier. The blood-brain barrier is a barrier that removes foreign substances causing the injection of medication in the brain to be difficult. With the use of low intensity focused ultrasound (LIFU), the blood-brain barrier can be opened to allow for medication to access the targeted area. The use of LIFU was tested on animals and had promising results for humans. A clinical trial led by Ali Rezai, M.D., director of the West Virginia University (WVU) Rockefeller Neuroscience Institute proved that LIFU could be used on humans, but further testing regarding the side effects of LIFU need to be conducted.